The follicles/eggs of women on GnRH-agonist "flare protocols" may be exposed to an exaggerated lupron-induced LH release in early follicular growth. We have tested if the high number of unfertilized ova and degenerated embryos found in superovulated goats previously treated with GnRH antagonist can be related to a prolongation of gonadotrophin down-regulation and/or alterations in follicular function during the period of administration of the superovulatory treatment, around 4 days after the end of the antagonist treatment. Currently, the GnRH rec. Numbers of embryos transferred and implantation rates were similar between the two groups (P=NS). Conclusion: this multicenter study shows that long protocol of GnRH agonist was better than short protocol in women with age of forty or above. The GnRH agonist protocol is designed to suppress the release of pituitary follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by desensitizing the pituitary receptors [ 1, 2 ].

The inclusion criteria were patients with adenomyosis, who had undergone surgery for adenomyosis and received GnRH agonist therapy for 3 months, underwent IVF with a short protocol and a long . The microdose flare group (Group I) had higher levels of E 2 on the day of hCG trigger (P = 0.03) and more number of MII oocytes (P = 0.04). I used micro-dose flare.My first IVF was the long lupron protocolIVF was the long lupron protocol This might not be problematic in "normal responders" but could be decidedly detrimental in "poor responders" and older women where endogenous basal LH levels are often raised. Multivariable logistic analysis was used to evaluate the difference of GnRH-a and GnRH-ant protocol in relation to CLBR. Antagonists (Cetrorelix 0.25 mg, Merck Serono) were added to stimulation protocol when the leading follicle achieved 13 mm in diameter. Because of this initial flare-up effect, agonists are usually administered in the mid-luteal phase of the previous cycle (better known as the long protocol).

Conclusion: A fixed multi-dose GnRH antagonist protocol is feasible for patients who are poor responders on a long agonist protocol; however, our study failed to demonstrate an overall improvement in ovarian responsiveness. Both protocols are simply, efficacious, started in the late follicular phase and do not have side effects. The "Long Protocol" which became the most popular procedure is based on a prolonged duration of GnRH -a treatment. Numerous demographic studies suggest a consistent decline in fecundity with increasing age (1). The pregnancy rates were also higher in the antagonist group, but the difference was not statistically significant. the long gnrh agonist (gnrh-a) protocol is a conventional protocol, probably the most widely used throughout the world even now, allows a quite good predictability of the work in ivf units, implies a low cancelation rate, and allows to get a relatively high number of pre-ovulatory follicles of retrieved oocytes and, as a consequence, of embryos Serum levels of sex hormones and ultrasound assessment of developing follicles were monitored on the 28th to the 35th day after GnRH agonist administration. Nevertheless, additional randomized controlled trials with better planning are needed to confirm these . Three approaches were employed in this retrospective analysis prior to gonadotropin stimulation: (1) a single injection of the GnRHa D-Trp 6 3.75 mg, (2) D-Trp 6 0.5 mg daily until menses followed by a dose reduction to 0.1 mg daily, 3) D-Trp 6 0.1 mg daily until menses followed by a dose reduction to 0.05 mg daily. About 15% of IVF cycles are in women over 40 and For women < or = 35 years of age the The GnRH-a protocol was associated with a low ET cancellation rate, high implantation rate and high live birth rate. In this protocol agonist treatment is either initiated in the early follicular (day 2 of the cycle), or the mid-luteal phase (day 21) of . Embryo euploid rate or endometrial receptivity might explain the difference in implantation rate between the GnRH-a and GnRH-ant protocols for young patients with DOR (PG3). The GnRH antagonist protocol led to better outcomes for women with a high ovarian reserve. To compare the efficacy and safety of FE 999049 (follitropin delta) and its personalized dosing algorithm in controlled ovarian stimulation for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) using a long gonadotropin-releasing hormone (GnRH) agonist protocol versus a short GnRH antagonist protocol. 41,46 lowering of testosterone concentrations also results in hot flashes and a decrease in Read "Comparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trial, Archives of Gynecology and Obstetrics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis, high . I've just done my second IVF cycle, trying for baby #3! However 44% will eliminate the use of this protocol in . Expand 6 PDF Save Alert 1-5 days) of the menstrual cycle; ovarian stimulation was started if pituitary downregulation was established (mostly 28 days after GnRH agonist administration) until trigger. The GnRH agonist long-acting protocol is one of the mainstream protocols of COS in China because of its advantages such as effectively improving endometrial receptivity and increasing the clinical . The fine print lowering of testosterone concentrations in adult men by surgical orchiectomy or by gnrh agonist or antagonist administration is associated with rapid and marked loss of bone mineral density, an increase in fat mass, and a loss of muscle mass and strength. A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. Utilized Propensity Score Matching (PSM) for sampling by up to 1:1 nearest neighbor matching to adjust the numerical difference and balance the confounders between groups. Find many great new & used options and get the best deals for Gonadotropin-Releasing Hormone (Gnrh) (UK IMPORT) Book NEW at the best online prices at eBay! Background This retrospective analysis compared the efficiency of the gonadotropin- releasing hormone (GnRH) antagonist (GnRH-ant) protocol and the GnRH agonist long (GnRH-a) protocol for patients with diminished ovarian reserve (DOR). The long-acting GnRH agonist follicular protocol: a full single dose of 3.75 mg long-acting GnRH agonist was administered in the early follicular phase (ca. Form the second day of menstrual cycle, 0.1 mg/d GnRHa will be injected by subcutaneous injection for 3-4 d. Gonadotropins will be added from the third day of menstrual cycle and the initial gonadotropin doses will be 225-300 IU/d . Free Online Library: Microdose flare-up gonadotropin-releasing hormone ( GnRH ) agonist versus GnRH antagonist protocols in poor ovarian responders undergoing intracytoplasmic sperm injection. The starting dose of FSH in the USA in most of the cases is higher then the one in Europe. Conclusion: Patients stimulated with the microdose flare protocol had significantly more E 2 levels with the recovery of more MII oocytes, but this did not transform to higher pregnancy rates. GnRH agonist significantly increased the chance of birth for women over 40 years old. In both groups, the hCG injection (Ovitrelle 6.500 IU/day; Merck-Serono) was . . A total of 1,233 patients with DOR (anti-Mullerian hormone <1.1 ng/mL) were recruited for this retrospective case-control study. In the GnRH-ant regimen, gonadotropin injections at a dose of 300-450 IU/day were commenced on day 2 or 3 of the cycle. Therefore, gonadotropin releasing hormone (GnRH) agonist protocol has been developed and employed in the setting of IVF-ET treatment ever since 1980s. 1 GnRH Agonists GnRH is a decapeptide produced in the hypothalamus. The follicular-phase depot GnRH agonist protocol results in a higher live birth rate without discernible differences in luteal function and child health versus the daily mid-luteal GnRH agonist protocol: a single-centre, retrospective, propensity score matched cohort study Ying Zhang, Wenxian Zhao, Yifan Han, Xin Chen, Shaoyuan Xu, Yueyue Hu, Download Citation | Administration of depot GnRH agonist prior to programmed frozen-thawed embryo transfer does not improve the live birth rate in ovulatory women: A large, multi-center . In this chapter, we will address the GnRH agonist protocols for IVF. There is still much controversy regarding the optimal GnRH-a protocol. GH and GnRH agonist therapy have been proposed in children near the age of puberty. Oral contraceptive pretreatment is frequently used for scheduling cycles in patients undergoing a gonadotrophin-releasing hormone agonist (GnRHa) protocol, and it has been reported that oral contraceptives significantly reduce weekend oocyte retrievals ( Barmat et al., 2005 ; Huirne et al., 2006 ). The bottom line This study found that the GnRH agonist protocol was better for women over 40 or those with low ovarian reserve. The commonest way of giving the GnRH agonist is the so-called long protocol. The initial treatment dose of gonadotropin is much higher in the older age group, and it runs in between 225 to 300 IU/d. GnRH-antagonists induce a direct block of GnRH receptor with a rapid decrease in LH and FSH, preventing LH surge. For those who want to get an effective and safe outcome, and a shorter treatment period, GnRH-ant is a suitable choice. Gonadotropin-releasing hormone (GnRH) receptor agonists are still the most commonly used androgen deprivation treatment (ADT) drugs for prostate cancer in clinical practice. This is the oldest and still the most commonly used protocol in clinical practice. The follicular-phase depot GnRH agonist protocol results in a higher live birth rate without discernible differences in luteal function and child health versus the daily mid-luteal GnRH agonist. Conclusion: GnRH-ant protocol was comparable with GnRH-a protocol in clinical outcomes, obstetric and perinatal outcomes, and with a lower risk of OHSS. COH usually includes the co-administration of gonadotropins and gonadotropin-releasing hormone (GnRH) analogues; the two most commonly used protocols are the long GnRH-agonist (GnRHa) suppressive protocol and the multiple-dose GnRH-antagonist (GnRHant) COH protocol. When GnRH agonists are used, a sudden increase in pituitary gonadotropins occurs. The GnRH-ant protocol has better clinical pregnancy outcomes when the endometrial thickness is in the medium thickness range of 7-10 mm, and the clinical pregnancy rate and live birth rate of the Gn RH-a protocol show a significant downward trend. However, when the meta-analysis was applied to the four trials that had used GnRH-ant versus flare-up protocols, a significantly higher number of retrieved oocytes (P=0.032; WMD: -0.51, 95% CI -0.99, -0.04) was observed in the GnRHa protocols. Transported via the portal circulation, GnRH stimulates gonadotrophs in the anterior pituitary gland to release two gonadotropins: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). results: in the study, the early miscarriage rate in women undergoing the ultra-long gnrh-a protocol was significantly lower than those undergoing the long gnrh-a protocol (12.0% versus 26.5%, p = 0.045), whereas the differences in the rates of biochemical pregnancy, implantation, clinical pregnancy, and live birth in women between the two groups (Original Article, Report) by "Journal of Reproduction and Infertility"; Health, general Agonists (Biochemistry) Comparative analysis Fertilization in vitro,. Long GnRH-a Protocol. The injections are started on day 21 of the cycle preceding the treatment cycle and continued right up to the time that the stimulation is halted and the ovulation triggered. Of these, 162 were treated with the long GnRH agonist protocol (group I), and 168 with the fixed GnRH antagonist protocol (group II). The early-follicular long-acting GnRH agonist long protocol can be used as an ideal assisted reproductive technology (ART) pregnancy assistance program for patients with PCOS, but obese patients should be encouraged to lose weight before ART treatments to reduce the risk of GDM. The overall cancellation rate was higher in the antagonist group compared to the agonist group, but the difference was not significant (22.15% vs. 15.2%, P=NS . the patients used the ultrashort protocols with GnRH agonist (GnRH-a, and recombinant Follicle-Stimulating Hormone for controlled ovarian hyperstimulation (COH). They were divided into two groups . 431 Pharmacologic GH therapy may partially overcome the effects of higher doses of glucocorticoids, and GnRH agonist will delay the progression of puberty, permitting more time to grow. In 56% there is no age limits for the use of long protocol of GnRH agonists. GnRH Agonist Long-Acting Protocol Each woman received a GnRH agonist (Diphereline, 3.75mg, Beaufort-Ipson, France) on the 2nd to 4th day of menstruation (follicular phase). The agonist/antagonist conversion protocol (A/ACP): With the A/ACP, GnRH antagonist (Ganirelix, Cetrotide, and Orgalutron) is . Free shipping for many products! A total of 15 . Two protocols has been designed for assisted reproduction technology (ART) treatment: multiple-dose protocol and a single-dose.